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With Plus series models Synology promised not to force people to use their enterprise-class drives HAT5310.
We also regularly receive emails from Synology users about the drives they are using. So often those drives are not on the compatibility lists. This included 20TB drives.
People also have figured out how to change their locking mechanism on XS series models.
If I have to guess whether their Ironwolf Pro drives will work - I would say yes.
Otherwise here is their shy list. They have no time or interest in testing any other drives.
Enterprise 3.5" SATA HDD Synology HAT5310 HAT5310-18T 1401 18TB
Enterprise 3.5" SATA HDD Synology HAT5310 HAT5310-8T 1401 8TB
Enterprise 3.5" SATA HDD Synology HAT5310 HAT5310-8T 1402 8TB
Enterprise 3.5" SATA HDD Synology HAT5300 HAT5300-16T 1401 16TB
Enterprise 3.5" SATA HDD Synology HAT5300 HAT5300-16T 1402 16TB
Enterprise 3.5" SATA HDD Synology HAT5300 HAT5300-12T 1401 12TB
Enterprise 3.5" SATA HDD Synology HAT5300 HAT5300-8T 1401 8TB
Enterprise 3.5" SATA HDD Synology HAT5300 HAT5300-4T 1401 4TB
Enterprise 3.5" SATA HDD Synology HAT5300 HAT5300-4T 1402 4TB
NAS 3.5" SATA HDD Seagate IronWolf ST12000VN0008 - 2YS101 SC60 12TB
NAS 3.5" SATA HDD Seagate IronWolf ST10000VN000 - 3AK101 SC60 10TB
NAS 3.5" SATA HDD Seagate IronWolf ST8000VN004 - 3CP101 SC60 8TB
NAS 3.5" SATA HDD Seagate IronWolf ST6000VN001 - 2BB186 SC60 6TB
NAS 3.5" SATA HDD Seagate IronWolf ST4000VN006 - 3CW104 SC60 4TB
NAS 3.5" SATA HDD Seagate IronWolf ST3000VN006 - 3CW10G SC60 3TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21EAZSTA 0601 14TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21EEZSTA 0601 14TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21EUZSVA 0601 14TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21EXZSTA 0601 14TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21EYZSTA 0601 14TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21CAZSTA 0601 12TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21CEZSTA 0601 12TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21CUZSVA 0601 12TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21CXZSTA 0601 12TB
NAS 3.5" SATA HDD Toshiba N300 HDWG21CYZSTA 0601 12TB
NAS 3.5" SATA HDD Toshiba N300 HDWG11AAZSTA 0603 10TB
NAS 3.5" SATA HDD Toshiba N300 HDWG11AEZSTA 0603 10TB
NAS 3.5" SATA HDD Toshiba N300 HDWG11AUZSVA 0603 10TB
NAS 3.5" SATA HDD Toshiba N300 HDWG11AXZSTA 0603 10TB
NAS 3.5" SATA HDD Toshiba N300 HDWG11AYZSTA 0603 10TB
NAS 3.5" SATA HDD Toshiba N300 HDWG480AZSTA 0601 8TB
NAS 3.5" SATA HDD Toshiba N300 HDWG480EZSTA 0601 8TB
NAS 3.5" SATA HDD Toshiba N300 HDWG480UZSVA 0601 8TB
NAS 3.5" SATA HDD Toshiba N300 HDWG480XZSTA 0601 8TB
NAS 3.5" SATA HDD Toshiba N300 HDWG480YZSTA 0601 8TB
NAS 3.5" SATA HDD Toshiba N300 HDWG460AZSTA 0601 6TB
NAS 3.5" SATA HDD Toshiba N300 HDWG460EZSTA 0601 6TB
NAS 3.5" SATA HDD Toshiba N300 HDWG460UZSVA 0601 6TB
NAS 3.5" SATA HDD Toshiba N300 HDWG460XZSTA 0601 6TB
NAS 3.5" SATA HDD Toshiba N300 HDWG460YZSTA 0601 6TB
NAS 3.5" SATA HDD Toshiba N300 HDWG440AZSTA 0601 4TB
NAS 3.5" SATA HDD Toshiba N300 HDWG440EZSTA 0601 4TB
NAS 3.5" SATA HDD Toshiba N300 HDWG440UZSVA 0601 4TB
NAS 3.5" SATA HDD Toshiba N300 HDWG440XZSTA 0601 4TB
NAS 3.5" SATA HDD Toshiba N300 HDWG440YZSTA 0601 4TB
NAS 3.5" SATA HDD Toshiba MN08AD MN08ADA800 0601 8TB
NAS 3.5" SATA HDD Toshiba MN08AD MN08ADA600 0601 6TB
NAS 3.5" SATA HDD Toshiba MN08AD MN08ADA400E 0601 4TB
NAS 3.5" SATA HDD Toshiba MN08ACA*** MN08ACA16T 0601 16TB
NAS 3.5" SATA HDD Toshiba MN07ACA*** MN07ACA14T 0601 14TB
NAS 3.5" SATA HDD Toshiba MN07ACA*** MN07ACA12T 0601 12TB
NAS 3.5" SATA HDD Toshiba MN06ACA*** MN06ACA10T 0603 10TB
NAS 3.5" SATA HDD Western Digital Red Plus WD140EFGX - 68B0GN0 85.00A85 14TB
NAS 3.5" SATA HDD Western Digital Red Plus WD120EFBX - 68B0EN0 85.00A85 12TB
NAS 3.5" SATA HDD Western Digital Red Plus WD101EFBX - 68B0AN0 85.00A85 10TB
NAS 3.5" SATA HDD Western Digital Red Plus WD80EFZZ - 68BTXN0 81.00A81 8TB
NAS 3.5" SATA HDD Western Digital Red Plus WD60EFZX - 68B3FN0 81.00A81 6TB
NAS 3.5" SATA HDD Western Digital Red Plus WD40EFZX - 68AWUN0 81.00B81 4TB
NAS 3.5" SATA HDD Western Digital Red Plus WD30EFZX - 68AWUN0 81.00B81 3TB
NAS 3.5" SATA HDD Western Digital Red Plus WD20EFZX - 68AWUN0 81.00B81 2TB
Surveillance 3.5" SATA HDD Seagate SkyHawkAI ST16000VE000 EV02 16TB
Surveillance 3.5" SATA HDD Seagate SkyHawkAI ST14000VE0008 EV02 14TB
Surveillance 3.5" SATA HDD Seagate SkyHawkAI ST12000VE0008 EV02 12TB
Surveillance 3.5" SATA HDD Seagate SkyHawkAI ST10000VE0008 EV02 10TB
Surveillance 3.5" SATA HDD Seagate SkyHawk ST8000VX004 - 2M1101 AV01 8TB
Surveillance 3.5" SATA HDD Seagate SkyHawk ST6000VX001 - 2BD186 CV11 6TB
Surveillance 3.5" SATA HDD Seagate SkyHawk ST3000VX009 CV11 3TB
Surveillance 3.5" SATA HDD Western Digital Purple WD121PURZ - 85GUCY0 81.H0A80 12TB
Surveillance 3.5" SATA HDD Western Digital Purple WD102PURZ - 85BXPY0 81.00A82 10TB
Surveillance 3.5" SATA HDD Western Digital Purple WD82EJRX - 89AD9Y0 82.00A82 8TB
Surveillance 3.5" SATA HDD Western Digital Purple WD82EVRX - 52DZFY0 82.00A82 8TB
Surveillance 3.5" SATA HDD Western Digital Purple WD82PURX - 64GVLYO 82.00A82 8TB
Surveillance 3.5" SATA HDD Western Digital Purple WD82PURX - 69GVLY0 82.00A82 8TB
Surveillance 3.5" SATA HDD Western Digital Purple WD82PURX - 78GVLY0 82.00A82 8TB
Surveillance 3.5" SATA HDD Western Digital Purple WD82PURZ - 85TEUY0 82.00A82 8TB
Surveillance 3.5" SATA HDD Western Digital Purple WD60EJRX 6TB
Surveillance 3.5" SATA HDD Western Digital Purple WD60PURX - 64T0ZY0 80.00A80 6TB
Surveillance 3.5" SATA HDD Western Digital Purple WD60PURZ - 85ZUFY1 80.00A80 6TB
Surveillance 3.5" SATA HDD Western Digital Purple WD40EJRX 4TB
Surveillance 3.5" SATA HDD Western Digital Purple WD40PURX - 64GVNY0 80.00A80 4TB
Surveillance 3.5" SATA HDD Western Digital Purple WD40PURZ 4TB
Surveillance 3.5" SATA HDD Western Digital Purple WD30EJRX 3TB
Surveillance 3.5" SATA HDD Western Digital Purple WD30PURX 3TB
Surveillance 3.5" SATA HDD Western Digital Purple WD30PURZ 3TB
Surveillance 3.5" SATA HDD Western Digital Purple WD20EJRX 2TB
Surveillance 3.5" SATA HDD Western Digital Purple WD20PURX 2TB
Surveillance 3.5" SATA HDD Western Digital Purple WD20PURZ 2TB
Enterprise 2.5" SATA SSD Synology SAT5210 SAT5210-3840G SCEMH3.2 3.84TB
Enterprise 2.5" SATA SSD Synology SAT5210 SAT5210-1920G SCEMH3.2 1.92TB
Enterprise 2.5" SATA SSD Synology SAT5210 SAT5210-960G SCEMH3.2 960GB
Enterprise 2.5" SATA SSD Synology SAT5210 SAT5210-480G SCEMH3.2 480GB
Enterprise 2.5" SATA SSD Synology SAT5200 SAT5200-3840G SCEMJ2.1 3.84TB
Enterprise 2.5" SATA SSD Synology SAT5200 SAT5200-1920G SCEMJ2.1 1.92TB
Enterprise 2.5" SATA SSD Synology SAT5200 SAT5200-960G SCEMJ2.1 960GB
Enterprise 2.5" SATA SSD Synology SAT5200 SAT5200-480G SCEMJ2.1 480GB